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KMID : 0378019940370040091
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New Medical Journal
1994 Volume.37 No. 4 p.91 ~ p.96
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The Efficacy and Safety of Clarithromycin (Klaricid) in Acute Maxillary Sinustitis
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Abstract
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The efficacy and safety of clarithromycin (Klaricid) in the treatment of acute sinusitis were evaluated in. a open, non-comparative, outpatient study. Thirty-three patients (16 males, 17 females) were randomly assigned to receive clarithromycin 500mg (two 250mg tablets) 12-hourly- orally.
Clinical signs and symptoms, sinus culture, blood and urine laboratory profile, and simple sinus radiography were assessed prior to treatment, at four days during treatment, and at 2days after treatment.
Clarithromycin achieved a clinical success rate of 97.0% within 2 days after treatment and radiologic resolution or improvement was observed in 87.9% of patients. There was no abnormal findings in laboratory tests during treatment. Adverse events were reported for 9.1% of patients and gastrointestinal disturbances, such as indigestion and diarrhea, were commonly occurring adverse event in the treatment of clarithromycin.
The results of this study suggest that clarithromycin is effective and well tolerated in the treatment of acute maxillary, sinusitis.
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